Avaliação da Influência da Valinomicina via Bomba de Na⁺/K⁺ na Comunicação Molecular por Sinalização de Ca²⁺ em Astrócitos

Ittalo S. Silva, Kaique Rijkaard de Sousa Oliveira, Ricardo de S Farias, Carlos Danilo Regis

DOI: 10.14209/SBRT.2020.1570661636

Evento: XXXVIII Simpósio Brasileiro de Telecomunicações e Processamento de Sinais (SBrT2020)

Keywords: Sinalização de Ca²⁺ Astrócitos Valinomicina Bomba de Na⁺/K⁺

Abstract

Ca²⁺-Signaling-based Molecular Communication (MC) implies the propagation of Ca²⁺ ions through cells by diffusion, which is influenced by the presence of concentration regulative structures in the plasma membrane, as the Na⁺/K⁺ pump. The valinomycin is a substance that operates via Na⁺/K⁺ pump to facilitate the transportation of those molecules through the membrane. Thus, this paper implemented a MC system, in order to evaluate the influence of the valinomycin in the Ca²⁺-Signaling in astrocytes. The activity of the valiomycin led both the Ca²⁺ propagation in the cytosol and the gain of the system to increase 9.4% and about 7.85 dB, respectively.

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